Cosmelan Therapy for the Treatment of the Mask of Pregnancy

(The Treatment of Melasma, Chloasma and Hyperpigmentation)


Mask of Pregnancy
  Cosmelan for the treatment of Melasma, Chloasma and Hyperpigmentation.
Cosmelan for the treatment of Melasma, Chloasma and Hyperpigmentation.

Doctors in Orange County California Laser


Cosmetic Center

 Orange County, California
Orange County, California 92649
Fax: 800-840-9439

Doctors in Orange County California Laser And Cosmetic Center, of Orange County, California, recently instituted an affective new treatment for melasma and chloasma, also known as the mask of pregnancy and hyperpigmentation due to hormones.


What is melasma?

Melasma is a skin condition presenting as brown patches on the face of adults. Both sides of the face are usually affected. The most common sites of involvement are the cheeks, bridge of nose, forehead, and upper lip.

What causes melasma?

The precise cause of melasma is unknown. People with a family history of melasma are more likely to develop melasma themselves. A change in hormonal status may trigger melasma. It is commonly associated with pregnancy and called chloasma, or the "mask of pregnancy." Birth control pills may also cause melasma, however, hormone replacement therapy used after menopause.

What is Cosmelan?

Cosmelan® is a Depigmentation treatment based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Cosmelan® formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain. Its principal action is the elimination of melanin patches on the face (melasma and chloasma).

What are the advantages of Cosmelan®?

The Cosmelan® Depigmentation treatment offers a series of major advantages and benefits compared with other types of depigmentation products found in the market:

bulletVery effective in all types of melasma
bulletRapid and easy depigmenting action
bulletCompatible with ALL skin types (Fitzpatrick I VI)
bulletLight peeling effect
bulletRejuvenates the skin
bulletTreatment can be used all year round
bulletBeneficial for acne patients
bulletDoes not contain TCA
bulletHigh safety margin

What results can I expect after using Cosmelan®?

In 99% of the cases, the disappearance of the blemishes improves by 95%...

ONE WEEK after starting the Cosmelan® Depigmentation treatment, a noticeable significant improvement of the skin is observed! The reduction of the treated blemish is detected and the appearance of new luminous and rejuvenated skin is present.

At the end of the Cosmelan® Depigmentation treatment, the blemishes start to disappear altogether, so that, although the patient may be able to "locate" the place where the spot was, the truth is that the pigmentation will have disappeared and nobody will be able to see it just by looking at it.

What active ingredients are in Cosmelan®?

  1. Cosmelan® 1 - Cream (10g)
  2. Azelaic Acid, Kojic Acid, Phytic Acid, Ascorbic Acid, Arbutine, Titanium Dioxide
  3. Cosmelan® 2 Maintenance Cream (30g)
  4. Titanium Dioxide, Kojic Acid, Phytic Acid, Ascorbic Acid

How does the Cosmelan® process work?

The process consist of two parts: First stage is applied in your physician's office: Basically is the cleansing of the skin and the application of a yellow mustard color mask (Cosmelan 1).

The physician will evaluate your skin type and determine what skin type you have. The physician will then cleanse your face and degrease the area to be treated. Immediately following the degreasing step, you will be applied Cosmelan® 1 which is a yellow mustard mask. The mask will be left on for a total of 4-8 hours depending on your skin type.

You will go home with the mask on.

After the action time has elapsed, you will remove the mask with water and a neutral cleanser.

Immediately following the cleansing of the face, you will apply the mesoestetic® Hydra-vital factor K cream.

Second stage is the Home Maintenance: It consists of the daily application and continual use of the Cosmelan 2 cream. The cream is applied three times to the day, the first week following the application of the mask, twice a day the second week, and once a day the third week forward.

How do I use Cosmelan® at home?

The Cosmelan® Depigmentation treatment initiated at the medical office must be continued at home, on a daily basis, according to the guidelines indicated.

Clean Face completely, every time mesoestetic(r) Cosmelan 2 is applied.

Apply a thin layer of mesoestetic(r) Cosmelan 2 all over face mask style, with a light, circular movement.

Apply mesoestetic(r) Hydra-vital factor K to the face and neck with a light, circular motion 15 minutes after applying mesoestetic(r) Cosmelan 2. Use daily.

What should I expect in my first day and second day after the Cosmelan® mask?

During the first two days of the treatment, the skin may turn red.

If the skin is very sensitive, the patient may experience an itching feeling.

Slight burning and tightening of the skin is also absolutely normal, especially during the first 24 to 48 hours after starting the treatment.

To relieve these problems, it is advisable to apply the mesoestetic(r) Hydra-vital factor K whenever necessary

What should I expect in my Third and fourth day?

After the third or fourth day, the skin appears healthy and luminous and the marks begin to fade.

Reddening of the Skin

The reddening that occurs on the face after applying the

mesoestetic(r) Cosmelan® 1 treatment is similar to the effects of day-long exposure to the sun in the snow without protection. (Intense reddening in photo type I and II and practically non existent in photo type IV and V)


Flaking may occur on all skin types (and more intensely in photo types I and II) between the second and third day. In this case it is advisable to apply the mesoestetic(r) Hydra-vital factor K cream, repeating this every two hours on the day when the flaking is most intense.

Can I stop the Cosmelan® treatment at any given time?

No, the treatment must not be interrupted under any circumstances, during the whole time prescribed.

Can I combine the Cosmelan® Treatment with other treatments?

It is completely forbidden to combine the Cosmelan® Depigmentation treatment with other depigmentation treatments, as the appearance of undesired effects cannot be guaranteed.

Is Cosmelan® the same as a TCA peel?

No, a TCA peel uses trichloroacetic acids (which are stronger than glycolic acids and penetrate deeper into the skin) to destroy and remove outer layers of the skin. During the 10-to-15-minute procedure, the patient feels a burning sensation and local anesthesia may be recommended. There is moderate discomfort and swelling of the treated areas for about a week. Healing and toughening of the new skin takes place for a few weeks following a TCA peel, but most patients look presentable enough to return to their normal activities after about a week.

Cosmelan® is a depigmentation treatment with a light peeling effect and does NOT require anesthesia nor involves any down time. The treatment does not cause pain or annoyance

Do I need to discontinue my everyday activities in order to use Cosmelan®?

No, Cosmelan® is a very versatile product that be incorporated to each individual life style.

Can Cosmelan® be applied in other parts of the body?

Yes, even though the protocol is recommended for the face, in most cases can be used on the top of the hands and sometimes in the chest area.

Can I use Cosmelan® during the summer?

Yes, Cosmelan® can be used all year round.

Can the blemishes return if I stop using Cosmelan?

In order to avoid blemishes from retuning, it is necessary to be disciplined with the Cosmelan regimen. On the days you do not follow the Cosmelan protocol, you should at least use a sun block of SPF 40+.

It is also advisable to apply Cosmelan 2 at night on the days you had more sun exposure.






Medical Affiliates and associates of California Doctors Laser Cosmetic Center may be located in a city near you. Please call (800) 840-9439 for more information.